Phototherapy for mycosis fungoides.
Indian J Dermatol Venereol Leprol
;
2015 Mar-Apr; 81(2): 124-135
Artigo
em Inglês
| IMSEAR
| ID: sea-158255
ABSTRACT
Background:
Both phototherapy and photochemotherapy have been used in all stages of mycosis fungoides since they improve the symptoms and have a favourable adverse effect profi le. Materials andMethods:
We performed an extensive search of published literature using keywords like “phototherapy”, “photochemotherapy”, “NBUVB”, “PUVA”, “UVA1”, “mycosis fungoides”, and “Sezary syndrome”, and included systematic reviews, meta-analysis, national guidelines, randomized controlled trials (RCTs), prospective open label studies, and retrospective case series. These were then arranged according to their levels of evidence.Results:
Five hundred and forty three studies were evaluated, of which 107 fulfi lled the criteria for inclusion in the guidelines. Conclusions andRecommendations:
Photochemotherapy in the form of psoralens with ultraviolet A (PUVA) is a safe, effective, and well tolerated fi rst line therapy for the management of early stage mycosis fungoides (MF), that is, stage IA, IB, and IIA (Level of evidence 1+, Grade of recommendation B). The evidence for phototherapy in the form of narrow-band UVB (NB-UVB) is less robust (Level of evidence 2++, Grade of recommendation B) but may be considered at least as effective as PUVA in the treatment of early-stage MF as an initial therapy. In patients with patches and thin plaques, NB-UVB should be preferentially used. PUVA may be reserved for patients with thick plaques and those who relapse after initial NB-UVB therapy. For inducing remission, three treatment sessions per week of PUVA phototherapy or three sessions per week of NB-UVB phototherapy may be advised till the patient achieves complete remission. In cases of relapse, patients may be started again on PUVA monotherapy or PUVA may be combined with adjuvants like methotrexate and interferon (Level of evidence 2+, Grade of recommendation B). Patients with early-stage MF show good response to combination treatments like PUVA with methotrexate, bexarotene or interferon- α-2b. However, whether these combinations hold a signifi cant advantage over monotherapy is inconclusive. For late stage MF, the above-mentioned combination therapy may be used as fi rst-line treatment (Level of evidence 3, Grade of recommendation C). Currently, there is no consensus regarding maintenance therapy with phototherapy once remission is achieved. Maintenance therapy should not be employed for PUVA routinely and may be reserved for patients who experience an early relapse after an initial course of phototherapy (Level of evidence 2+, Grade of recommendation B). Bath-water PUVA may be tried as an alternative to oral PUVA in case the latter cannot be administered as the former may show similar effi cacy (Level of evidence 2-, Grade of recommendation C). In pediatric MF and in hypopigmented MF, both NB-UVB and PUVA may be tried (Level of evidence 3, Grade of recommendation D).
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fototerapia
/
Fotoquimioterapia
/
Humanos
/
MEDLINE
/
Micose Fungoide
/
PubMed
Tipo de estudo:
Ensaio Clínico Controlado
/
Guia de Prática Clínica
Idioma:
Inglês
Revista:
Indian J Dermatol Venereol Leprol
Ano de publicação:
2015
Tipo de documento:
Artigo
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