Addition of citral controls ROS and reduces toxicity in 5-fluo rouracil treated Schizosaccharomyces pombe cells.
Indian J Exp Biol
;
2015 Mar; 53(3): 152-157
Artigo
em Inglês
| IMSEAR
| ID: sea-158403
ABSTRACT
In systemic therapy, chemotherapeutic drugs, often, cause considerable side effects; and combination of natural compounds lessen the extent of such effects. In the present study, combined effect of citral and 5-fluorouracil was studied in Schizosaccharomyces pombe cells. The antagonistic combination index found was at 0.01 and 0.025 mM of citral with 40 µg or higher concentration of 5-fluorouracil. The combined treatment was so effective that higher number of cells underwent apoptosis compared to individual treatment of 5-fluorouracil. Citral controlled ROS levels and increased survival of normal cells. Several differentially expressed proteins observed in the citral treatment could further help understanding its mechanism of action.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Schizosaccharomyces
/
Proteínas Fúngicas
/
Espécies Reativas de Oxigênio
/
Apoptose
/
Estresse Oxidativo
/
Monoterpenos
/
Relação Dose-Resposta a Droga
/
Avaliação Pré-Clínica de Medicamentos
/
Fluoruracila
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2015
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS