Histopathological study of adrenocortical masses with special references to Weiss score, Ki-67 index and p53 status.
Indian J Pathol Microbiol
;
2015 Apr-Jun 58(2): 175-180
Artigo
em Inglês
| IMSEAR
| ID: sea-158578
ABSTRACT
Background:
Adrenal mass present with wide morphological spectrum and clinical manifestation, which can give rise to diagnostic confusion. Proper categorization is essential for individualized treatment. Aim andObjective:
(1) Application of Weiss criteria to differentiate between benign and malignant adrenocortical neoplasm (2) co-relation of Ki-67 and p53 expression with the Weiss score. Materials andMethods:
A prospective, observational study was conducted in the Department of Pathology in collaboration with department of Endocrinology and Urology of a tertiary care hospital including 19 patients presented with clinically symptomatic or radiologically detected adrenocortical mass. Tissue for histopathological study was obtained in the form of the postoperative material. Histopathological categorization was done, and Weiss score was calculated in all tumors. Ki-67 and p53 immunohistochemistry were performed.Result:
A total 19 cases of adrenal mass lesions were included. Cushing syndrome was the presenting symptoms in 26.3% adrenocortical masses. All patients with tumors with Weiss’s score <3 (Group 1) were alive after 24 months of followup compared to 20% of those with Weiss’s score >3 (Group 2). Statistically signifi cance difference was noted in average weights and size of the tumors. Distribution of Ki-67 and p53 expression between Group 1 and Group 2 were compared and found statistically highly signifi cant with Fisher’s two-tailed P < 0.001.Conclusion:
The combination of the meticulous evaluation of clinical, morphological and immunohistochemical profi le helps in proper categorization of adrenocortical mass.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Tipo de estudo:
Estudo observacional
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
2015
Tipo de documento:
Artigo
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