Determinants of Acute Dystonia in First Episode of Psychotic Patients Treated with Haloperidol and Centbutindole.

ABSTRACT

Objectives: To assess the factors affecting of acute dystonia in first episode psychotic patients taken haloperidol and centbutindole Method and Procedure Total 54 patients (Schizophrenia, manic, psychotic) taken for the study from the psychiatry O.P.D. K.G.M.C Lucknow. The age group of patients were between the 17 to 55 years. This study was double blind and prospective. Patients were randomly administered Holoperidol (5 mg) TDS or Centbutindole (1.5 mg) TDS. The total period of study was 2 weeks, if any abnormal movements developed during this period the criteria for acute dystonia was applied. Tools Semi structured proforma, International Classification of Disease — 10. Diagnostic and research criteria for neuroleptic induced acute dystonia, Scale for assessment of torsion dystonia. Beck and Refaelsen Mania Rating Scale for manic patient only, Brief Psychiatric Rating Scale On all patients was used. Result: The results show that acute dystonia was higher among the manic patients, younger age, married, male between the age group 17-25 year and duration of illness 1-3 months. It was also higher among those patients who have psychiatric family history.