Environmental biotoxicity screening of some pyrrole and 1,4-dihydropyridine heterocyclic derivatives.

ABSTRACT

Synthesis of pyrrole 1-3 and 1,4-dihydropyridine derivatives 4-6 were prepared from condensation method and synthesized compounds were screened for environmental biotoxicity such as Brine shrimp cytotoxicity, Ichthyotoxic, Larvicidal and Nematicidial activities. Among the compounds 3 and 6 shows that highly toxic (LD50 8.72 and 12.30 μg/mL) against Brain shrimp cytotoxic screening and compound 3 and 6 was highly toxicity ( LD50 5.01 and 7.75 μg/mL) against Antifeedant screening (ichthyotoxic profile). The compounds 3 and 6 was highly active (LD50 12.88 μg/mL, and 14.79 μg/mL) against Larvicidal activity and compound 3 and 6 was highly active (LD50 8.20 μg/mL, and 7.43 μg/mL) against Nematicidal activity.