Variation Of HbS Frequency In Indian Population : Role Of P. Falciparum And Other Factors.

HbS is not merely confined to tribes, but also exists in other caste populations. As far as the distribution in tribes in concerned, three distinct foci are discernible conforming to three distinct major tribal clusters. However; wide variability exists within populations. The populations of mixed origin have elevated HbS frequencies. Overall correlation of plasmodium falciparum with HbS incidence is negligible, but significant positive correlation with % population spread of HbS to castes is an important observation. The Orissa situation needs special mention. The HbS gene is found in various caste populations including high castes and those with an AFI index of above 25% 0 with -thalassemia, it is expected that HbS frequency is in the process of increasing in these caste populations. Significant correlations obtained between districtwise distribution of HbS and latitude, % tribal population, % tribal cultivators and % tribal literacy are important from the point of view of understanding the population dynamics of HbS distribution in the Indian population.