Clinical forms and determinants of different locations of extrapulmonary tuberculosis in an African country.
Artigo
em Inglês
| IMSEAR
| ID: sea-159941
ABSTRACT
Background:
Extra-pulmonary tuberculosis (EPTB) accounts for about 15% to 36% of all cases of TB and its prevalence has significantly increased with the advent of the global pandemic of human immune-deficiency virus (HIV) infection. A few studies are available on the determinants of EPTB.Aims:
To determine the distribution and determinants of the main locations of EPTB in the context of high endemicity for HIV infection.Methods:
This was a cross-sectional study among patients aged >15 years, receiving care in the pneumology service of the Yaounde Jamot Hospital, between October 2010 and December 2011. Logistic regressions were used to investigate potential determinants of different locations of EPTB.Results:
Of the 788 eligible patients admitted during the study period, 100 (12.7%) had isolated EPTB, and 158 (20.1%) had both PTB and EPTB. Among 258 patients definitively included, 162 (62.8%) were men and the median age was 33 (25.75-44) years. Frequent extra-pulmonary locations of tuberculosis were lymph nodes (126 patients, 48.3%), pleura (121 patients, 46.4%) and peritoneum (25 patients, 9.6%). Using isolated pleural TB as a referent, independent determinants of isolated lymph node tuberculosis were HIV infection [odds ratio (95% CI), 2.58 (1.25-5.32)], duration of symptoms >6 weeks [2.41 (1.11-5.22)] and pulmonary involvement [2.39 (1.14-5.05)]. HIV infection [2.23 (1.06- 4.70)] and duration of symptoms >6 weeks [2.31 (1.08-4.96)] were also independent determinants of multifocal/disseminated tuberculosis.Conclusion:
EPTB with or without concomitant PTB is frequent in this setting, with HIV infection being the main determinant.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Tuberculose dos Linfonodos
/
Peritonite Tuberculosa
/
Tuberculose Pleural
/
Humanos
/
Masculino
/
Camarões
/
Infecções por HIV
/
Fatores de Risco
/
Adulto
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Fatores de risco
País/Região como assunto:
África
Idioma:
Inglês
Ano de publicação:
2013
Tipo de documento:
Artigo
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