Effect of luteinizing hormone releasing hormone analogues on testosterone metabolism in vitro —A study with mature rat ventral prostates.
J Biosci
;
1988 Jun; 13(2): 105-108
Artigo
em Inglês
| IMSEAR
| ID: sea-160645
ABSTRACT
The effects of two luteinizing hormone releasing hormone analogues (a superagonist and an antagonist) on the conversion of testosterone to dihydrotestosterone in homogenates prepared from adult rat ventral prostates were studied. At higher doses, the superagonist showed a significant dose-dependent inhibition of the conversion of testosterone to dihydrotestosterone. In comparison, the antagonist showed only a marginally inhibitory trend. The implications of these observed effects vis-a-vis the use of the analogues in the endocrine management of prostatic cancer have been discussed.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Idioma:
Inglês
Revista:
J Biosci
Ano de publicação:
1988
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS