Mitochondrial functions during experimentally induced cardiac hypertrophy.

ABSTRACT

When the hearts of albino rats are subjected to pressure-induced stress through constriction of ascending aorta, changes in the mitochondrial functions are observed as early as 24 h after the imposition of the stress. These include the abolition of oxidative phosphorylation, decrease in the energy dependent [45Ca]-uptake and decrease in the rate of energized swelling. A large influx of calcium ions and an increase in the fluidity of mitochondrial membranes also occur in this period. At later stages of hypertrophy (17, 28, 40%), these mitochondrial functions gradually return to normal levels.