Antiserum directed against cell surface antigens is lethal to Leishmania donovani promastigotes.
J Biosci
;
1988 Jun; 13(2): 129-138
Artigo
em Inglês
| IMSEAR
| ID: sea-160651
ABSTRACT
The purified flagellar fraction of Leishmania donovani promastigotes consists of 30-35 polypeptides. Antiserum raised against this fraction reacts with both flagella and pellicular membrane antigens as evident from immunoblot and immunofluorescence studies. Only 3 of these immunoreactive polypeptides are flagellum-specific. The antiserum agglutinates the cells and inhibits their growth in liquid culture medium. Moreover, glucose uptake and glucose-stimulated oxygen uptake of the promastigotes are significantly inhibited by the antiserum. The results indicate that the antiserum has a profound lethal effect on the in vitro propagation of the parasite.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Idioma:
Inglês
Revista:
J Biosci
Ano de publicação:
1988
Tipo de documento:
Artigo
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