Age-related prevalence of antibodies to infective-larvae of Wuchereria bancrofit in normal individuals from a filaria-endemic region.
J Biosci
;
1995 Mar; 20(2): 167-174
Artigo
em Inglês
| IMSEAR
| ID: sea-160990
ABSTRACT
Antibody isotypic levels (IgM, IgE and IgG subclasses) to infective larvae (L3) of Wuchereria bancrofti were measured in 104 normal individuals from a filaria-endemic region in Orissa. The titres of antibodies were considerably higher in adults (n = 25, 25·1 ± 3·8 year) than in children (n = 52, 7·1 ± 2·1 year). Young children (n = 14) less than four years were seronegative to all isotypes other than IgM, the sero-conversion to which was achieved in the children (n=15) by the age of 7·5±1·2 years. The prevalence of other isotypes increased with age and reached a maximum in early adulthood (18·6 ± 1·6 years), which persisted in older adults (> 30 years). However, the increase in IgG3 prevalence with age was less marked. IgG2 was detected only after 10 years of age. Compared to the high prevalence (100%) of IgM, IgE, IgG1, and IgG2, in adults. IgG3 and IgG4 prevalences were low, 35% and 28% respectively. IgA level to L3 antigen was found to be extremely low even in adults. These data indicate that the prevalence of L3 antibodies was different for different isotypes and the acquisition of antibody response essentially followed an age dependent pattern.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Tipo de estudo:
Estudo de prevalência
/
Fatores de risco
Idioma:
Inglês
Revista:
J Biosci
Ano de publicação:
1995
Tipo de documento:
Artigo
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