Evaluation of Cassia singueana extract on stomach HCL production and gastric emptying in rats.

ABSTRACT

Investigation of the effects of the extract from C. singueana leaves on stomach hydrochloric acid (Hcl) production following histamine administration and on gastric emptying was carried out in rats. Cassia singueana extract (CSE) at 250 and 750 mg/kg significantly (p<0.050) decreased both gastric free-Hcl and total acids as well as the quantity of meal emptied from the stomach when compared with solvent control. The extract at 250 mg/kg exerted a significant decrease in gastric emptying more than cimetidine (100 mg/kg). CSE contains alkaloids, tannins, sterols and terpenes but no flavonoids, saponins, carbohydrates, reducing sugars, starch nor polyuronides.