Effects of Vitamin E, morin, rutin and quercetin against dox induced oxidative stress.

ABSTRACT

Doxorubicin (DOX) is a potent chemotherapeutic agent for the treatment of a variety of human malignancies. Increasing oxidative stress appears to play a major model to increase free radical producing and decrease activities of endogenous antioxidant enzymes. The present study, the development of oxidative stress was prevented by using natural antioxidant vitamin E (50 IU/kg body weight) and flavonoids morin, rutin and quercetin a poly phenolic compounds available in plants. The four weeks treatment of flavonoids (20mg/kg body weight) was affectively reduced the oxidative stress by DOX (10mg/kg body weight) on two dose treatment. The flavonoids maintained the biochemical parameters at optimum levels and they were significantly controlled by the flavonoids. The conclusion of this study is that the flavonoids are natural antioxidants, that they can ameliorate the biochemical markers. The authors suggest that the diet rich flavonoids can useful in the protection of certain diseases like cardiomyopathy (CAD, hypertension, heart failure and stroke), diabetes, cancers and oxidative stress etc., and this model can suggests that fields of Biochemistry and Pharmacology had good scope to evaluate the metabolic diseases and disorders.