Relationship between Physico-chemical Parameters and Phylogenetics Study of Human Low Density Lipoprotein Receptor-Related Protein (LRP).

ABSTRACT

In this study, 11members of human low density lipoprotein receptor-related protein (LRP) sequences was retrieved from UniProtKB/ SWISS-PROT protein database and was analyzed for information about their structural, functional and phylogenetic features. This was achieved by using many established biocomputational tools which was available at their latest version. This study shows that LRP 12 and 3 are closely related with LRP8 being their nearest neighbor. In all, it was observed that there were very low possession of certain essential amino acid like glycine, proline and a very high aliphatic in all the LRP family. Considering the evolutionary history, functional domains, high aliphatic index, overall proportion of glycine and proline and the established role of one (LRP8) of this closely related LRP in diseases, it is thus predicted that the other closely related LRP3 and 12 molecules may be important candidate in investigating the aetiopathology of Myocardial infarction1diseases or other heart related disorder.