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Effects of Cissus populnea and Panax ginseng on Flutamide-Induced Testicular Defect in Pre-Pubertal Male Rats.
Br J Med Med Res ; 2013 Jan-Mar; 3(1): 173-181
Artigo em Inglês | IMSEAR | ID: sea-162804
ABSTRACT

Aim:

This study was carried out to determine the effects of Cissus populnea and Panax ginseng on flutamide-induced testicular toxicities in pre-pubertal rats. Place and Duration of Study Department of Anatomy, College of Medicine of the University of Lagos, Lagos – Nigeria, between May and December 2010.

Methodology:

20 male immature (25 days old) Wistar rats were used. They were randomly divided into 4 groups; 1 control and 3 treatment groups. Group A served as control, group B was administered flutamide and Cissus populnea, group C was administered flutamide and Panax ginseng and group D was administered flutamide alone. Body weight and testicular weights were measured. Hormonal assay for testosterone, FSH and LH were done using Enzyme-Linked Immunosorbent Assay (ELISA). Histopathology of the testis was also investigated.

Result:

There were no statistically significant differences in serum testosterone levels in all three treatment groups when compared with the control group. There was a significant increase in the serum LH level in group D when compared with the control group (p<0.05). Serum FSH level in group B showed a significant increase when compared with the control group (p<0.05). The histological evidences of testis in group D showed a reduction in lining cells of the seminiferous tubules; however, in the other three treatment groups they were similar to the control group.

Conclusion:

The results suggest that Cissus populnea and Panax ginseng ameliorates the adverse effects of flutamide on the testis.

Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Idioma: Inglês Revista: Br J Med Med Res Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Idioma: Inglês Revista: Br J Med Med Res Ano de publicação: 2013 Tipo de documento: Artigo