Perspectives of Fullerene Derivatives in PDT and Radiotherapy of Cancers.

ABSTRACT

Nanoparticles of fullerenes and their water-soluble derivatives have been firmly introduced into solution of medical problems. Although there are still debates about their toxicity and long-term consequences of their application in the clinic, the success of fullerenes application in some sections is undeniable, in particular, in photodynamic therapy (PDT) of cancer tumors. Besides there are interesting data on radiotherapy where fullerenes appear to be more transporters than drugs, but due to own cytoprotective properties, the fullerene adducts can also participate in the combined treatment. This review evaluates the status of these sections of fullerene chemistry in terms of development and recent trends.