Phytochemical Screening and Antipyretic Effect of Curcuma zedoaria Rosc. (Zingiberaceae) Rhizome.
Artigo
em Inglês
| IMSEAR
| ID: sea-163385
ABSTRACT
Aims:
To investigate the antipyretic effect of ethanol extract of Curcuma zedoaria Rosc. (Zingiberaceae) rhizome in animal model. StudyDesign:
Extraction of plant constituents and evaluation of elevated body temperature lowering activity. Place and Duration of Study Department of Pharmacy, North South University, Dhaka between October 2012 and August 2013.Methodology:
We have performed phytochemical screening and evaluated antipyretic activity of ethanol extract of the rhizome of Curcuma zedoaria by yeast-induced pyresis method. Ethanol extract of Curcuma zedoaria rhizome was administered to healthy rats.Results:
The results showed that the ethanol extract of Curcuma zedoaria significantly reduced yeast-induced elevated body temperature in rats in a dose dependent manner and the antipyretic effect at a dose of 750 mg/kg was comparable to that of the standard antipyretic drug paracetamol (10 mg/kg). Phytochemical screening of ethanol extract showed presence of tannins, flavonoids, saponins, alkaloids, terpinoids, carbohydrates and steroids as main constituents in Curcuma zedoaria extract some of which may possess antipyretic activity.Conclusion:
The results justify the traditional use of the ethanol extract of Curcuma zedoaria in the treatment of fever.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Idioma:
Inglês
Ano de publicação:
2014
Tipo de documento:
Artigo
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