Detection and spectrophotometric determination of tinidazole.

ABSTRACT

A direct spectrophotometric method was developed by the authors for the quantitative determination of tinidazole in a pure form and also in other pharmaceutical formulations. The method was based on the diazotization reaction between nitro group of the drug sample, sulphanilamide and NEDA. In the present method, the reddish-purple colour dye formed, exhibited a maximum absorbance at 540nm. Beer’s law was found to be obeyed in the range of 100-600μgmL-1for tinidazole with detection limits of 0.04μgmL-1. The present method was found to be precise, accurate for the qualitative and quantitative determinations.