The study of antiepileptic activity of clove oil in chemical induced convulsions in mice.

ABSTRACT

Background: The objective was to evaluate and compare the effect of an extract of essential oil of clove with the standard sodium valproate on pentylenetetrazole (PTZ) induced seizures in animal models. Methods: A total of 30 mice were taken, they were given a chemo shock at the concentration of 60 mg/kg using PTZ. 30 mice were divided into 5 groups of 6 animals each the control group received distilled water 5 ml/kg i.p., standard received injection sodium valproate 200 mg/kg i.p. another group received sesame oil – 10 ml/kg i.p. (control), test groups received Clove oil - 0.075 ml/kg i.p., clove oil - 0.1 ml/kg i.p., respectively. All the injections were given 30 mins before the administration of PTZ. Results: Clove oil produced a significant antiepileptic effect at all the doses. Conclusion: Clove oil has shown significant antiepileptic activity in mice.