Mechanisms of oxidative stress and myocardial protection during open‑heart surgery.
Ann Card Anaesth
;
2015 Oct; 18(4): 555-564
Artigo
em Inglês
| IMSEAR
| ID: sea-165265
ABSTRACT
Cold heart protection via cardioplegia administration, limits the amount of oxygen demand. Systemic normothermia with warm cardioplegia was introduced due to the abundance of detrimental effects of hypothermia. A temperature of 32–33°C in combination with tepid blood cardioplegia of the same temperature appears to be protective enough for both; heart and brain. Reduction of nitric oxide (NO) concentration is in part responsible for myocardial injury after the cardioplegic cardiac arrest. Restoration of NO balance with exogenous NO supplementation has been shown useful to prevent inflammation and apoptosis. In this article, we discuss the “deleterious” effects of the oxidative stress of the extracorporeal circulation and the up‑to‑date theories of “ideal’’ myocardial protection.
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Índice:
IMSEAR (Sudeste Asiático)
Idioma:
Inglês
Revista:
Ann Card Anaesth
Ano de publicação:
2015
Tipo de documento:
Artigo
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