Effect of Polyherbal Formulation on Metabolic Derangements in Experimental Model of High Fructose Diet Induced Metabolic Syndrome.

ABSTRACT

High fructose diet induces metabolic syndrome. Therefore an attempt has made to evaluate the effect of Polyherbal formulation in male Wistar rats by oral administration of 350 mg/Kg body weight (HF1) and 500 mg/ Kg body weight (HF2). The clinical symptoms established in high fructose diet induced metabolic syndrome were ameliorated by Poly herbal formulation. Food, water intake was increased in high fructose diet fed rats. Body weight, abdominal waist and Body mass index were increased in only high fructose fed rats whereas reduced with poly herbal formulation. Atherogenic index and Blood pressure were increased in only high fructose fed rats but reduced in rats supplied with polyherbal formulation (HF1 and HF2) along high fructose. Biochemical components like fasting blood glucose levels, triglycerides, total cholesterol, LDL, VLDL, SGOT, SGPT, Uric acid, Malondialdehyde (MDA) were increased in only high fructose fed group rats whereas these components were reduced and normalised in groups of rats fed with high fructose diet for 7 weeks in association with Herbal formulation HF1, HF2 for last three weeks separately.HDL-C levels were found increased in rats even though supplied with polyherbal formulation. Histopathology results of pancreas and liverof only high fructose fed rats indicated the infiltration of inflammatory cells and fat accumulation which was ameliorated with HF1 and HF2.