Hepatoprotective Activity of a Unani Polyherbal Formulation “Kabideen” in CCl4 Induced Liver Toxicity in Rats.

ABSTRACT

Objective: To evaluate the hepatoprotective effect of Kabideen Syrup in rats treated with carbon tetrachloride. Methods: In hepatotoxic rats, liver damage was studied by assessing parameters such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin, total proteins, and cholesterol and lipid peroxidation. Histopathological study of the liver in experimental animals was also undertaken. Results: Hepatic damage as evidenced by a rise in the levels of AST, ALT, ALP, bilirubin cholesterol and Malondialdehyde (MDA) and decreased level of total protein in serum. Liver showed a tendency to attain near normalcy in animals co-administered with kabideen (50 ml/kg) significantly reduced the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and cholesterol levels and increased the total protein levels when compared to the CCl4 group. The histopathological findings showed a significant difference between the Kabideen (50ml/kg) and CCL4 treated groups. Conclusion: The study substantiates the hepatoprotective potential of Kabideen.