Evaluation of Neuroprotective Effect of Quercetin and Coenzyme Q10 in Ethanol Induced Neurotoxicity in Mice.

ABSTRACT

Ethanol is a principle ingredient of alcoholic beverages with potential neuronal-genotoxicity, and associated neuronal oxidative DNA damage, neurodegeneration in the CNS and neurocognitive deficits is well documented. Chronic consumption of alcohol is associated with disturbances of mnemonic functions and behavioural deficit. DNA-damaging molecules such as reactive oxygen species (ROS), lipidperoxidation product malondialdehyde (MDA) and acetaldehyde are potent genotoxic agents.Combined application of Quercetin and Coenzyme Q10 ameliorated the neurotoxicity by significantly reducing the potential biomarkers of oxidative stress, augmenting neurotransmitter, and cellular DNA and ATP contents. These results suggest that combined application of Quercetin and Coenzyme Q10 will be beneficial in prevention of neurodegeneration and cognitive deficits associated with alcoholism and these therapeutic interventions could have a clinical implication associated with alcoholism. The combined neuroprotective treatment of Quercetin and Coenzyme Q10 has been proven to ameliorate the neurotoxicity induced by ethanol.