T-Cell Assay as a Diagnostic Tool for Tuberculosis.

ABSTRACT

This study aimed to estimate the specificity and sensitivity of a whole blood IFN-g assay (ELISPOT) test for diagnosis in childhood tuberculosis. 96 patients, less than 18 years of age, diagnosed and commenced on anti-tubercular therapy were enrolled and tested. 47 age and sex matched controls were also tested. 23 tests were deemed invalid and analysis done on the remainder. The sensitivity was 53.3% in confirmed cases and less in other groups. The specificity was high at 97.9%. This test can be an useful aid in the diagnosis of tuberculosis.