A Rare Variant of Oral Lichen Planus-Bullous Form.

ABSTRACT

Lichen planus (LP) is an immune-mediated chronic inflammatory disease that is seen mainly affecting the skin, nails, hair, and mucous membranes. Oral LP (OLP) has about 0.4‑5.3% potential to be malignant. If the disease is sufficiently characterized, the diagnosis can be made from the clinical features alone; but a biopsy is recommended to confirm the diagnosis and to exclude the presence of dysplasia and malignancy. OLP seems to be mediated by an antigen-specific mechanism, thereby activating the cytotoxic T-cells and non-specific mechanisms such as degranulation of mast cells and activation of matrix metalloproteinase. Pathogenesis of OLP may involve both antigen-specific and nonspecific mechanisms. Here, we report a case of bullous LP in a 44-year-old female patient, discussing clinical features and etiopathogenesis.