Oral Zinc Supplementation for Reducing Mortality in Probable Neonatal Sepsis: A Double Blind Randomized Placebo Controlled Trial.
Indian Pediatr
;
2013 April; 50(4): 390-393
Artigo
em Inglês
| IMSEAR
| ID: sea-169764
ABSTRACT
Objective:
To study the role of Zinc in the treatment of neonatal sepsis.Design:
Double blind, randomized, placebo controlled trial.Setting:
Tertiary Care Hospital.Participants:
614 neonates with probable neonatal sepsis. Intervention The drug group (n=307) received 1mg/kg/day of elemental zinc, and placebo group (n=307) received the placebo, in addition to antibiotic therapy and supportive care, till the final outcome (discharge/death). OutcomeMeasures:
Decrease in mortality rates (primary outcome), duration of hospital stay and need of higher lines of antibiotic therapy (secondary outcomes) were tested.Results:
Baseline characteristics of the two groups were similar. No statistically significant differences between drug and placebo group were found in mortality rate (9.77% vs 7.81 %; P=0.393), mean duration of hospital stay (142.85±69.41 hrs, vs. 147.99±73.13 hrs; P=0.841), and requirement of higher lines of antibiotic therapy (13.35% vs 12.05%, P=0.628) after supplementation.Conclusions:
This study does not report decrease in mortality rates, duration of hospital stay and requirement of higher lines of antibiotic therapy following zinc supplementation in neonatal sepsis.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Inglês
Revista:
Indian Pediatr
Ano de publicação:
2013
Tipo de documento:
Artigo
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