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Oral Zinc Supplementation for Reducing Mortality in Probable Neonatal Sepsis: A Double Blind Randomized Placebo Controlled Trial.
Indian Pediatr ; 2013 April; 50(4): 390-393
Artigo em Inglês | IMSEAR | ID: sea-169764
ABSTRACT

Objective:

To study the role of Zinc in the treatment of neonatal sepsis.

Design:

Double blind, randomized, placebo controlled trial.

Setting:

Tertiary Care Hospital.

Participants:

614 neonates with probable neonatal sepsis. Intervention The drug group (n=307) received 1mg/kg/day of elemental zinc, and placebo group (n=307) received the placebo, in addition to antibiotic therapy and supportive care, till the final outcome (discharge/death). Outcome

Measures:

Decrease in mortality rates (primary outcome), duration of hospital stay and need of higher lines of antibiotic therapy (secondary outcomes) were tested.

Results:

Baseline characteristics of the two groups were similar. No statistically significant differences between drug and placebo group were found in mortality rate (9.77% vs 7.81 %; P=0.393), mean duration of hospital stay (142.85±69.41 hrs, vs. 147.99±73.13 hrs; P=0.841), and requirement of higher lines of antibiotic therapy (13.35% vs 12.05%, P=0.628) after supplementation.

Conclusions:

This study does not report decrease in mortality rates, duration of hospital stay and requirement of higher lines of antibiotic therapy following zinc supplementation in neonatal sepsis.

Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Tipo de estudo: Ensaio Clínico Controlado Idioma: Inglês Revista: Indian Pediatr Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Tipo de estudo: Ensaio Clínico Controlado Idioma: Inglês Revista: Indian Pediatr Ano de publicação: 2013 Tipo de documento: Artigo