Hematological Alterations and Thymic Function in Newborns of HIV-Infected Mothers Receiving Antiretroviral Drugs.
Indian Pediatr
;
2013 June; 50(6): 567-572
Artigo
em Inglês
| IMSEAR
| ID: sea-169846
ABSTRACT
Objectives:
To investigate the effects of antiretroviral (ARV) drugs on hematological parameters and thymic function in HIVuninfected newborns of HIV-infected mothers. Studydesign:
Cross sectional study.Setting:
Chiang-Mai University Hospital, Chiang-Mai, Thailand. Participants/Patients 49 HIV-uninfected and 26 HIV-infected pregnancies.Methods:
Cord blood samples of newborns from HIVuninfected and HIV-infected mothers were collected. Hematological parameters were measured using automatic blood cell count. T-cell receptor excision circles (TRECs) levels in cord blood mononuclear cells (CBMCs), CD4+ and CD8+ T-cells were quantified using real-time PCR. Main OutcomeMeasures:
Hemotological parameters and thymic function.Results:
Newborn of HIV-infected mother tended to have lower mean levels of hemoglobin than those of HIV-uninfected mother (137 ± 22 vs 146 ± 17 g/L, P = 0.05). Furthermore, mean of red blood cell (RBC) counts and hematocrit and median of TRECs in CD4+ T-cells in the newborns of the former were significantly lower than those of the latter [3.6 ± 0.7 vs 4.8 ± 0.6 x 1012 cells/L, P <0.001; 0.40 ± 0.07 vs 0.46 ± 0.05 L/L, P <0.001 and 0.53 (IQR 0.03-5.76) vs 13.20 (IQR 2.77-27.51) x 10-3 pg/μL, P = 0.02, respectively].Conclusion:
ARV drugs altered hematological parameters and thymic function (TRECs CD4+ T-cells) in HIV-uninfected newborns of HIV-infected mothers.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Tipo de estudo:
Estudo observacional
Idioma:
Inglês
Revista:
Indian Pediatr
Ano de publicação:
2013
Tipo de documento:
Artigo
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