Role of dopaminergic mechanisms in the central amygdalar nucleus in the regulation of stress-induced gastric ulcer formation in rats.
Artigo
em Inglês
| IMSEAR
| ID: sea-17046
ABSTRACT
Microinjections (i/am) of dopamine (DA) antagonists, haloperidol or clozapine (1 and 5 micrograms) into the central amygdalar nucleus (CEA) produced dose-related aggravations in cold-restraint (3 h at 4 degrees C) stress-induced gastric ulcer formation in rats. On the other hand, DA (10 micrograms, i/am), its agonist, apomorphine (5 mg/kg, ip) and its precursor, l-Dopa (100 mg/kg, ip) significantly inhibited stress ulcerogenesis. Pretreatment of rats (i/am) with clozapine antagonized or reversed the gastric cytoprotective effects of DA, apomorphine and l-Dopa. The results indicate that the CEA is important for the observed gastric cytomodulatory effects of both centrally and peripherally administered dopaminergic agents during stressful experiences.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Úlcera Péptica
/
Ratos
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Ratos Endogâmicos
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Estresse Fisiológico
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Masculino
/
Clozapina
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Antagonistas de Dopamina
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Dibenzazepinas
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Relação Dose-Resposta a Droga
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Haloperidol
Idioma:
Inglês
Ano de publicação:
1989
Tipo de documento:
Artigo
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