Spirometric Evaluation in Juvenile Systemic Lupus Erythematosus.

ABSTRACT

Objective: Spirometric evaluation in juvenile systemic lupus erythematosus. Methods: Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), FEV1/ FVC, forced expiratory flow between 25-75% of vital capacity (FEF25-75%) and peak expiratory flow rate (PEFR) of 21 patients with juvenile SLE (jSLE) were compared to controls. Result: Reduced FVC and FEF25-75% was found in 18 and 9 patients, respectively. All had normal FEV1/FVC. None had respiratory complaint. When compared to controls, patients had significantly reduced FVC [mean (SD)1.97 (0.56) vs 2.35 (0.60), P=0.002] and FEF25-75% [2.19 (0.83) vs 2.63 (0.76), P=0.028] but similar FEV1/FVC [86.87(7.03) vs 86.72 (6.35), P=0.639]. Conclusion: jSLE patients had significant restrictive pattern and small airway involvement.