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In vitro studies on the effect of certain natural products against hepatitis B virus.
Artigo em Inglês | IMSEAR | ID: sea-17170
ABSTRACT
Picroliv (active principle from Picrorrhiza kurroa), its major components picroside I, catalpol, kutkoside I, kutkoside, andrographolide (active constituent of Andrographis paniculata), silymarin and Phyllanthus niruri extract were tested for the presence of anti hepatitis B virus surface antigen (anti HBs) like activity. HBsAg positive serum samples obtained from hepatitis B virus (HBV) associated acute and chronic liver diseases and healthy HBsAg carriers were used to evaluate the anti-HBs like activity of compounds/extract. The latter were mixed with serum samples and incubated at 37 degrees C overnight followed by HBsAg screening in the Elisa system. A promising anti-HBsAg like activity was noted in picroliv (and its major components) catalpol, P. niruri which differed from the classical viral neutralization. Picroliv also inhibited purified HBV antigens (HBsAg and HBsAg) prepared from healthy HBsAg carriers. The in vitro testing system appears to be a suitable model to identify an agent active against HBV, prior to undertaking detailed studies.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Ácido Vanílico / Feminino / Humanos / Masculino / Extratos Vegetais / Anticorpos Anti-Hepatite / Criança / Vírus da Hepatite B / Cinamatos / Adulto Idioma: Inglês Ano de publicação: 1990 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Ácido Vanílico / Feminino / Humanos / Masculino / Extratos Vegetais / Anticorpos Anti-Hepatite / Criança / Vírus da Hepatite B / Cinamatos / Adulto Idioma: Inglês Ano de publicação: 1990 Tipo de documento: Artigo