Maternal Overt Hypothyroidism and Neurobehavioral Outcome of Neonates: A Cohort Study from an Iodine-deficient Area of Northern India.
Indian Pediatr
;
2015 Oct; 52(10): 864-866
Artigo
em Inglês
| IMSEAR
| ID: sea-172134
ABSTRACT
Objective:
To study the relation between maternal overt hypothyroidism and neurodevelopmental outcome of neonates in iodine-deficient region of Northern India (Kashmir Valley).Design:
Prospective cohort study.Setting:
Endocrinology department of a tertiary-care hospital.Participants:
82 hypothyroid pregnant women were enrolled and followed up till delivery. The neonates born to this group represented the case neonates. 51 euthyroid healthy pregnant women were selected as control group. The neonates born to these mothers served as controls. Main outcomemeasures:
Early neonatal behavioral assessment at 3-4 weeks of age.Results:
The mean TSH and free T4 in neonates of mothers with well controlled hypothyroidism was significantly different from those born to mothers with poorly controlled hypothyroidism and controls in 1st trimester, but the difference was statistically insignificant for 2nd and 3rd trimester values.Conclusion:
Overt maternal hypothyroidism in iodine-deficient area constitutes a risk factor for an abnormal neurobehavioral development of affected child.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Idioma:
Inglês
Revista:
Indian Pediatr
Ano de publicação:
2015
Tipo de documento:
Artigo
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