Zinc Supplementation in Preterm Neonates and Neurological Development: A Randomized Controlled Trial.
Indian Pediatr
;
2015 Nov; 52(11): 951-955
Artigo
em Inglês
| IMSEAR
| ID: sea-172240
ABSTRACT
Objective:
To assess the effect of zinc supplementation on neuro-development and growth of preterm neonates.Setting:
Referral neonatal unit of a teaching hospital.Design:
Open-labeled Randomized controlled trial.Participants:
100 preterm neonates. Intervention Participants randomized to receive oral zinc (study group) or not (controls). Main OutcomeMeasures:
Primary Neuro-development status at 40 weeks post conceptional age and at 3 month corrected age using Amiel-Tison neurologic assessment. Secondary anthropometry and serum alkaline phosphatase at 3 months corrected age.Results:
At 40 weeks post-conceptional age, greater number of zinc supplemented infants demonstrated alertness and attention pattern normal for their age (P=0.02). Higher number of controls showed signs of hyper-excitability at 40 week post-conceptional age (P=0.001) and 3 months corrected age (P=0.003). At 3 month corrected age, mean serum alkaline phosphatase level was significantly higher in the study group compared to controls.Conclusion:
Zinc supplementation till 3 month corrected age in preterm breastfed infants improves alertness and attention pattern; and decreases signs of hyperexcitability, and proportion with abnormal reflexes.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Inglês
Revista:
Indian Pediatr
Ano de publicação:
2015
Tipo de documento:
Artigo
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