Respiratory functions in kidney mitochondria following paracetamol administration to young-adult & old rats.
Artigo
em Inglês
| IMSEAR
| ID: sea-17234
ABSTRACT
Effects of paracetamol treatment in vivo to young-adult (2-3 months) and old (22-24 months) rats at subtoxic (375 mg/kg) and toxic (750 mg/kg) doses on kidney mitochondrial energy metabolism were examined. Administration of paracetamol (both doses) to young-adult animals did not, in general, affect the respiratory functions of kidney mitochondria. On the other hand, treatment of toxic doses to aged animals resulted in decrease in the state 3 respiration rates with glutamate, pyruvate + malate and succinate as substrates. Succinoxidase activity was also impaired in this experimental group. With subtoxic doses, state 3 respiration rate was decreased only with pyruvate + malate as substrate. Results indicate that the in vivo administration of paracetamol impaired kidney mitochondrial energy metabolism in aged animals.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Consumo de Oxigênio
/
Ratos
/
Masculino
/
Envelhecimento
/
Ratos Wistar
/
Analgésicos não Narcóticos
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Avaliação Pré-Clínica de Medicamentos
/
Rim
/
Animais
/
Acetaminofen
Idioma:
Inglês
Ano de publicação:
1997
Tipo de documento:
Artigo
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