Influence of squalene feeding on plasma leptin, testosterone & blood pressure in rats.
Artigo
em Inglês
| IMSEAR
| ID: sea-17416
ABSTRACT
BACKGROUND & OBJECTIVES:
Obesity, hyperlipidaemia and hypercholesterolaemia are known risk factors in the pathogenesis of hypertension. Squalene has been shown to reduce serum cholesterol and triglycerides in dogs although its therapeutic use in high BP and obese patients has not been established. This study evaluates the effect of feeding high doses of squalene on plasma leptin, glucose, testosterone, blood pressure (BP) and body fat in rats.METHODS:
Wistar rats (male, 22 days old) were randomly divided into two groups receiving either regular control diet or a squalene-containing diet. After feeding squalene for 4 wk, 10 rats each from the squalene and control groups were sacrificed and blood samples were collected for measurement of leptin, cholesterol, triglycerides and testosterone. Blood pressure was monitored weekly.RESULTS:
Following squalene feeding, BP and body weight gain were lower in the squalene group. BP was significantly lower from 47 days of age in squalene fed group compared to controls. The levels of plasma leptin, glucose, cholesterol and triglycerides were significantly lower in squalene fed rats than those from the control group at 51 and 75 days of age. However, testicular weights (only 75 days) and testosterone levels were significantly higher in rats from the squalene group than those from the control group at days 51 and 75. INTERPRETATION &CONCLUSION:
Our results suggested that squalene may counteract the increase in body fat, BP and levels of plasma leptin, glucose, cholesterol and triglycerides. These effects of squalene may be further explored as a likely new approach for clinical management of high BP and obesity.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Tamanho do Órgão
/
Ratos
/
Esqualeno
/
Testículo
/
Testosterona
/
Pressão Sanguínea
/
Masculino
/
China
/
Ratos Wistar
/
Leptina
Tipo de estudo:
Fatores de risco
País/Região como assunto:
Ásia
Idioma:
Inglês
Ano de publicação:
2009
Tipo de documento:
Artigo
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