Potential Autoepitope within the Extracellular Region of Contactin-Associated Protein-like 2 in Mice.
Br J Med Med Res
;
2014 Jan; 4(1): 416-432
Artigo
em Inglês
| IMSEAR
| ID: sea-174919
ABSTRACT
Aims:
Implicated in autoimmune encephalitis, neuromyotonia and genetic forms of autism, here we report that contactin-associated protein-like 2 (CNTNAP2) contains a potential autoepitope within the extracellular region.Methodology:
CNTNAP2 sequence-similar regions (CSSRs) from human pathogens were identified. Sera from autistic and control children were obtained and analyzed for the presence of antibodies able to bind CSSRs. One such candidate CSSR was evaluated for evidence of autoimmune responses to CNTNAP2 in a mouse model of acute infection.Results:
Autistic and control children sera contained antibodies able to discrete regions of CNTNAP2. In a murine model of acute infection, a CSSR derived from the N-terminal extracellular region of CNTNAP2 resulted in anti-CNTNAP2 antibody production, proinflammatory cytokine elevation, cerebellar and cortical white matter T-cell infiltration as well as motor dysfunction.Conclusion:
Taken together, these data suggest that CNTNAP2 contains a potential autoepitope within the extracellular region.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Idioma:
Inglês
Revista:
Br J Med Med Res
Ano de publicação:
2014
Tipo de documento:
Artigo
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