A Study of Multi - Organ Involvement in Leptospirosis.

Background: Awareness about the infection is scarce especially in the developing countries as a consequence of which, it is rarely thought of in the differential diagnosis of febrile illnesses. Failure to diagnose leptospirosis is particularly unfortunate: severely ill patients often recover completely with prompt treatment but if therapy is delayed or not given, death or renal are likely to ensure. Methods: A total 50 patients who were admitted with fever at JSS hospital, medicine department over a period of 2 years that is during August 2005 to August 2007 who have been diagnosed to have leptospirosis fulfilling the inclusion and exclusion criteria. Present study design is a prospective study during which patient will be followed up during hospital stay, recovery and one month after discharge. Results: In our study out of 5 patients 16 patients (32%) had no complications, 34 patients (68%) have developed various complications. 4 patients (8%) developed ARF, 7 patients (14%) developed hepatitis, 17 patients (34%) ARF with Hepatitis, 2 patients (4%) Hepatitis with altered sensorium, 1 patient (2%) developed Myocarditis; Hepatitis; ARF, 1 patient (2%) developed ARF; ARDS; Hepatitis; Myocarditis, 2 patients (4%) ARDS with ARF and Hepatitis. Conclusion: Early diagnosis & initiation of treatment of leptospirosis prevents mortality and morbidity.