Bilateral Symmetrical Basal Ganglia Calcification with Atypical Presentation: A Case Series.

ABSTRACT

Physiological intracranial calcification is asymptomatic and is detected incidentally by neuroimaging. Pathological basal ganglia calcification (BGC) is caused by various causes such as metabolic disorders, infectious and genetic diseases, and others. The most common causes of pathological BGC are hypoparathyroidism and pseudohypoparathyroidism. We present three cases of bilaterally symmetrical BGC associated with hypoparathyroidism. All of them presented with seizures as the only presentation without any signs of hypocalcemia and without extrapyramidal features. One should not rule out hypoparathyroidism in the absence of other signs of hypocalcemia and extrapyramidal features. Biochemical analysis pertaining to hypoparathyroidism must be done. Timely treated patients can have a good prognosis.