Resistance to amoxicillin‑clavulanate and its relation to virulence‑related factors in Yersinia enterocolitica biovar 1A.

ABSTRACT

Recent studies have reported that the virulence factors (VFs) were detected more frequently in amoxicillin‑clavulanate (AMC) susceptible clinical isolates of Escherichia coli. Here, we have evaluated the relationship between VFs and AMC‑resistance phenotype in clinical isolates of Y. enterocolitica biovar 1A. The presence/absence of VFs was compared with their minimum inhibitory concentrations for AMC in strains of two serovars. We observed that the strains of the serovar O 6, 30‑6, 31 showed a similar relationship between the number of VFs and resistance to clavulanic acid as in E. coli but not of serovar O 6, 30. Variations in the promoters/complete coding sequences (CCDSs) of β‑lactamase gene (blaA) or the serological characteristics could not account for unusual susceptibility to AMC displayed by the strains of the serovar O 6, 30. Therefore, we speculate that since the clinical strains of serovar O 6, 30‑6, 31 originated from the environment they were less exposed to antibiotics compared to clinical strains of serovar O 6, 30. Thus, AMC susceptibility seems to be influenced by factors other than serotypes or promoters/CCDS of β‑lactamase genes.