Comparison of development methods based on UV/VIS spectrophotometry and ICP OES for the determination of iodine in pharmaceuticals.

ABSTRACT

In this study, methods based on UV-Vis spectrophotometry (Sandell-Kolthoff reaction) and inductively coupled plasma optical emission spectrometry (ICP OES) were developed in order to determine iodine in pharmaceuticals. A simple preparation of samples, which consisted in the solubilization by means of ultrasound, was performed using pure water as solvent. The developed analytical methods were validated employing limit of detection, precision and accuracy. The recovery range is 101.0% - 104.0% for the expectorant solutions, and 98.0% - 102.0% for the supplements using the ICP OES technique. For the UV-Vis spectrophotometric method, the recovery range is 96.0% - 98.0% for the expectorant solutions, and 96.0% - 98.3% for the supplements. These methods are simple and accessible, and might be used in the pharmaceutical field.