Serotonergic modulation of spinal cord sympathetic preganglionic neurone activity in cardiovascular regulation.
Artigo
em Inglês
| IMSEAR
| ID: sea-17699
ABSTRACT
The present study demonstrates the effect of activation of spinal serotonergic receptors on heart rate, blood pressure and cardiac arrhythmia induced by coronary artery ligation in cervical spinal cord transected and bilaterally vagotomized dogs. Intrathecal injection of serotonin (5-HT) evoked a fall in blood pressure (mean decrease, 16 +/- 3) and a decrease in heart rate (mean change, 24 +/- 6) and these effects were blocked by intrathecal pretreatment with methysergide. The magnitude of ventricular ectopics evoked by coronary artery ligation was decreased by serotonin (mean decrease, 31 +/- 5%), and this effect of serotonin was blocked by methysergide pretreatment intrathecally (mean change, 7 +/- 5%). Methysergide per se, increased the magnitude of ventricular ectopics (mean increase, 24 +/- 5%). The serotonergic receptors of the spinal cord appear to have an inhibitory influence on the cardiovascular functions.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Antagonistas da Serotonina
/
Medula Espinal
/
Feminino
/
Masculino
/
Fenômenos Fisiológicos Cardiovasculares
/
Serotonina
/
Receptores de Serotonina
/
Cães
/
Gânglios Espinais
/
Animais
Idioma:
Inglês
Ano de publicação:
1991
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS