Optical Quality and Tear Film Analysis after Various Lubricating Eye - Drops.

ABSTRACT

Purpose: To compare the optical quality and tear film analysis of normal and dry eye individuals after instilling various lubricating eye drops. Materials and Methods: A total of 50 eyes of 25 normal individuals and 20 eyes of 10 dry eye patients were studied using LipiView Interferometer (TearScienceInc, Morrisville, North Carolina, USA) Optical Quality Analysis System (OQAS) and HD Analyzer (Visiometrics, Terrassa, Spain). These patients were subjected to randomized use of drop A (polyethylene glycol 400 NF 0.4%, propylene glycol 0.3%), drop B (sodium carboxymethyl cellulose (CMC) and glycerin 0.9%), and drop C (sodium CMC-5 mg). The optical quality and tear film were analyzed at the end of 10 min, 40 min and 1 week. Results: The average interferometric units measured were 82.36, 74.28 and 71.4 with drops A, B and C, respectively. The average objective scatter index was 0.42 before using any drops and 0.48, 0.38 and 0.42 after drops A, B and C, respectively. The average modulation transfer function was 43.7 before drops and 39, 45.6 and 46 after usage of drops A, B, and C, respectively. Conclusion: The lipiview analysis suggested that drop A had a beneficial effect on the lipid layer of the tear film. Metrics on OQAS revealed that drops B and C showed improvement in MTF and OSI in normal as well as dry eye patients.