Comparative Study of Serum Malondialdehyde Levels as a Marker of Oxidative Stress in Patients of Pregnancy-induced Hypertension and Controls.

ABSTRACT

Hypertensive disorders are the most common medical complications of pregnancy with a reported incidence ranging between 5 and 10%. In pregnancy-induced hypertension, many complex homeostatic modifications occur, some are harmful to the mother and fetus, while others are beneficial. The objective of this study was to determine the serum malondialdehyde (MDA) in pregnancy-induced hypertension (PIH) and to compare them to that of normal pregnant women. Materials and methods: The study was carried out in the department of biochemistry which included total 30 patients of PIH age group of 20 to 40 years and age and sex matched controls. Serum MDA was estimated by method of Nourooz-Zadeh J et al using trichloroacetic acid and thiobarbituric acid. Mean and standard deviation were calculated for serum MDA. Statistical analysis was done using SPSS no. 17 and student t-test. In the present study, statistically significant increase in levels of lipid peroxidation MDA was observed PIH as compared to those in normal pregnant controls.