A Study on Association between Thyroid Stimulating Hormone Levels and Metabolic Syndrome Components.

ABSTRACT

Background: Since metabolic syndrome (MetS) and thyroid dysfunction (TD) are both characterized by a cluster of common abnormalities, it is possible that patients suffering from both disease entities might have compounded risk. This study was aimed to evaluate the pattern of TD in subjects with MetS and its relationship with components of the MetS. Methods: One hundred cases defined according to the International Diabetic Federation (IDF) criteria were evaluated for vital parameters, lipid and thyroid profile, along with other routine laboratory parameters. Results: There was a significant association of various metabolic syndrome parameters viz. body mass index(BMI), systolic blood pressure (SBP),diastolic blood pressure (DBP), total cholesterol(TC), triglycerides (TG) and fasting blood sugar(FBS) with TD (P<0.05). It was found that BMI, waist circumference (WC), SBP, total cholesterol (TC), triglyceride (TG) and FBS had significant (P<0.05) positive linear correlation whereas age and high density lipoprotein (HDL) had non-significant (P>0.05) negative correlation with thyroid stimulating hormone (TSH) levels. Conclusion: The prevalence of TD in patients with MetS was high; while subjects with SCH and elderly females were at increased risk.