Hs-CRP and Serum Uric Acid as Risk Factors and Prognostic Markers in Acute Myocardial Infarction.

ABSTRACT

Background: To study the role of inflammatory markers like hs-CRP and S. Uric Acid as risk factors and prognostic markers in acute myocardial infarction. Methods: A total of 100 cases admitted in ICU/CCU under Department of Medicine/cardiology, NIMS Medical College & Hospital Jaipur and 100 controls who were the normal age/sex matched during study period of 15 months i.e. August 2014 to October 2015 were taken into study based on inclusion and exclusion criteria. Blood samples were taken to measure hs-CRP and Uric Acid and patients were followed for 7 days in hospital. Tests of statistical significance were done using Chi-square Test, unpaired ’t’ test, fisher test. Results: Out of 100 age and sex matched cases and controls, 63% were having positive hs-CRP compared to 2% in controls (p< 0.001). Hyperuricemia was found in 23% cases compared to 4% in controls(p=0.0002). 44 patients developed different complications during follow up, out of which 40 were having positive hs-CRP (P < 0.001) and 22 were having hyperuricemia (p< 0.001). Conclusion: We found that hs-CRP and Uric Acid are risk factors for myocardial infarction and are good predictors of outcome following MI.