Central noradrenergic & dopaminergic modulation of brewer's yeast-induced inflammation & nociception in rats.
Artigo
em Inglês
| IMSEAR
| ID: sea-17774
ABSTRACT
The possibility of central noradrenergic and dopaminergic modulation of Brewer's yeast-induced peripheral inflammation was investigated in rats. Centrally administered noradrenaline (NA), amphetamine, which liberates NA and dopamine in the central nervous system and L-dopa, the precursor of dopamine significantly suppressed paw oedema. Conversely, the beta-adrenoceptor blocker, propranolol, catecholaminergic neuron degenerator, 6-hydroxydopamine (6-OHDA), dopaminergic antagonist, haloperidol and dopamine synthesis inhibitor, alpha-methyl para tyrosine (AMPT) augmented paw oedema. In addition, 6-OHDA and haloperidol produced significant reduction in pain threshold. The results of this study indicate that central NA and dopamine exert inhibitory effects on Brewer's yeast-induced peripheral inflammation.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Dor
/
Ratos
/
Saccharomyces cerevisiae
/
Simpatomiméticos
/
Masculino
/
Dopamina
/
Norepinefrina
/
Ratos Sprague-Dawley
/
Anfetamina
/
Inflamação
Idioma:
Inglês
Ano de publicação:
1997
Tipo de documento:
Artigo
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