Effect of pinacidil on the contractile response of cyclophosphamide-treated rat vas deferens.
Artigo
em Inglês
| IMSEAR
| ID: sea-17783
ABSTRACT
Effect of pinacidil, a K+ channel opener, was studied on contractility of cyclophosphamide-treated rat vas deferens. The mean IC50 value of pinacidil against 1 mmol barium chloride induced rhythmic contractions and 40 mmol potassium chloride induced tonic contractions was significantly (P < 0.01 and P < 0.001, respectively) increased in the cyclophosphamide treated group as compared to the control. The mean EC50 value of norepinephrine (NE) in the presence of pinacidil (10(-6) mol) was significantly (P < 0.001) increased in the cyclophosphamide treated group. These findings indicate that the responsiveness of rat vas deferens smooth muscle to pinacidil is reduced following cyclophosphamide treatment.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Ducto Deferente
/
Masculino
/
Canais de Potássio
/
Norepinefrina
/
Cálcio
/
Antineoplásicos Alquilantes
/
Pinacidil
/
Ciclofosfamida
/
Animais
Idioma:
Inglês
Ano de publicação:
1999
Tipo de documento:
Artigo
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