Response of the postnatal rat epididymis to estrogen & antiestrogens.
Artigo
em Inglês
| IMSEAR
| ID: sea-17826
ABSTRACT
The effect of androgen and estrogen antagonists on estrogen induced responses in the epididymis of rat was studied. Estradiol benzoate administered to male rates on day 5 of life increased the epididymal weight, absolute volume density of fibromuscular stroma and its eosinophilic leucocyte numbers. Testosterone administration (day 5 life) alone did not have any stimulatory effect on the epididymis as an organ or its peroxidase activity on days 15 or 20 of life. On the other hand, testosterone/85/287 negated estradiol induced increase in the absolute volume density, eosinophilic leucocyte accumulation and peroxidase activity. Tamoxifen (Tam) with inherent estrogenic activity acted both as an agonist and an antagonist. Results of present studies support the contention that nonsteroidal antiestrogens (CDRI-85/287 and Tam) can modulate estradiol induced epididymal responses during the postnatal period of male rat.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Masculino
/
Peroxidase
/
Tamanho Celular
/
Epididimo
/
Antagonistas de Estrogênios
/
Estrogênios
/
Animais
/
Índice Mitótico
Idioma:
Inglês
Ano de publicação:
1997
Tipo de documento:
Artigo
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