Association of micro and macrovascular complications with fatty liver in patients with type 2 diabetes mellitus.

ABSTRACT

Background:Fatty liver is a fairly common entity seen in the diabetic population. Studies showed that liver adiposity is independently associated with Insulin Resistance and can substantially increase the risk of various micro and macrovascular complications of diabetes mellitus. Aims: Identifying various micro and macrovascular complications and finding their association with fatty liver disease in type 2 diabetes patients. Material and methods: 141 diabetic patients admitted in a tertiary care center over a two year period were screened for fatty liver by ultrasonography of the abdomen and were classified into FL (fatty Liver) group and NFL (non fatty liver) group. All patients were investigated for complications like nephropathy, neuropathy, retinopathy, cardiac and peripheral vascular disease. Statistical analysis was done to find the association of complications with fatty liver. Results: out of 141 patients, 49 (35%) had fatty liver. Leading complication was neuropathy (31.2%), followed by nephropathy (11.3 %), retinopathy (10.6 %), cardiac disease (9.2%) and peripheral vascular disease (3.55). Between FL and NFL groups, Diabetic neuropathy (40.8% vs 23.9%) and cardiac disease (16.3% vs 5.4%) showed statical significance (p<0.05), while other complications were more or less equally prevalent in the two groups. Conclusions: Fatty liver is seen in one third of diabetic patients. vascular complications like neuropathy and cardiac disease are more commonly seen in diabetic patients with fatty liver than those without fatty liver.