Co‑existing ligneous conjunctivitis and IgG4‑related disease.

ABSTRACT

Herein, we elucidate that ligneous conjunctivitis (LC) was proved as an IgG4‑related disease (IgG4‑RD) by a series of pathologic studies from primary and recurrent episodes of an LC patient. LC was diagnosed based on clinical presentation and pathological appearance; furthermore, combined with serological examination and immunohistochemical study, the case also conformed to the diagnosis of IgG4‑RD. The IgG4‑RD, broadly discussed in recent times, is an idiopathic disease entity with tissue fibrosis possibly involving multiple organs. To the best of our knowledge, IgG4‑RD has never been reported with LC. By reporting the clinical course and literature review, we should pay attention to the association between these two diseases.