Expression and clinicopathological significance of antiapoptotis protein survivin in gallbladder cancer.
Indian J Pathol Microbiol
;
2016 Apr-June 59(2): 143-147
Artigo
em Inglês
| IMSEAR
| ID: sea-179448
ABSTRACT
Background:
Clinical significance of survivin (antiapoptosis protein) in gallbladder cancer is not yet established.Aims:
This study was performed to assess the expression pattern of survivin in benign and malignant gallbladder lesions using immunohistochemistry (IHC), and to assess its clinicopathological significance. Settings andDesign:
Prospective study from July 2012 to July 2014 was performed as a part of intramural research project. Materials andMethods:
Tissue samples from resected gallbladder for cholelithiasis (n = 27) and carcinoma gallbladder (n = 24) were evaluated for survivin expression by IHC using a scoring system. Their expression was correlated with different clinicopathological parameters. StatisticalAnalysis:
Fisher’s exact test, Student’s t‑test, and Chi‑square test were used as appropriate for data analysis. Kaplan–Meier methods were used to calculate overall and disease‑free survival rates among different groups. Two‑sided P < 0.05 was considered as significant.Results:
Benign group (19 females, age [mean ± standard deviation [SD]] 45 ± 14 years) and malignant group (20 females, age [mean ± SD] 48.9 ± 13.4 years) were comparable with respect to menopausal status, presence, size and types of stones. However, survivin expression was significantly higher (66.7%, 95% confidence interval [CI] 24–75) in gallbladder cancer than in cholelithiasis group (33%, CI 46–83), P = 0.025). Its expression did not correlate with gender, age, menopausal status, presence of gallstones or their size, number and type, tumor differentiation, and tumor stage.Conclusions:
Significantly higher expression of survivin protein in gallbladder cancer as compared to cholelithiasis group suggests its role in gallbladder carcinogenesis though it may not have prognostic value.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
2016
Tipo de documento:
Artigo
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